Bone Anabolic Effects of Basic Fibroblast Growth Factor in Ovariectomized Rats1
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چکیده
منابع مشابه
Bone Anabolic Effects of Basic Fibroblast Growth Factor in Ovariectomized Rats1.
The purpose of this study was to characterize the bone anabolic effects of basic fibroblast growth factor (bFGF) in ovariectomized (OVX) rats. Female Sprague Dawley rats were subjected to ovariectomy or sham surgery at 3 months of age and maintained untreated for 2 months post surgery. Groups of OVX rats were then treated iv with bFGF at doses of 100 or 200 microg/kg day for 7 or 14 days. Anoth...
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BACKGROUND Tendon injuries are common and it takes a long time for an injured tendon to heal. Adverse phenomena such as adhesion and rupture are associated with these injuries. Finding a method to reduce the time required for healing whichimproves the final outcome, will lead to decreased frequency and intensity of adverse consequences. This study was designed to investigate the effects ...
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In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture. Addition of FGF-2 to the serum-free medium inhibited lo...
متن کاملEffect of Local Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Subcutaneously Allotransplanted Ovarian Tissue in Ovariectomized Mice
OBJECTIVE One of the major obstacles to ovarian tissue preservation is delayed angiogenesis that leads follicles lost after transplantation. The aim of the present study was to investigate the effects of bFGF and VEGF on heterotopic transplanted ovarian tissue using a mouse model. METHODS Female mice underwent bilateral ovariectomy. Ovarian tissues encapsulated by fibrin hydrogels were transp...
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Systemic treatment of intact and ovariectomized rats with basic fibroblast growth factor (bFGF) has strong bone anabolic effects. These effects include marked increases in osteoblast number and activity along cancellous and endocortical bone surfaces, which result in accumulation of osteoid and augmentation of cancellous and cortical bone mass after only short-term treatment with bFGF. Osteocla...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1999
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.140.12.7195